Preferred Label : Bcl-2/Bcl-XL Inhibitor LP-118;
NCIt synonyms : Bcl-2/XL Inhibitor LP-118;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic proteins B-cell lymphoma-2
(Bcl-2) and Bcl-extra large (Bcl-XL), with potential pro-apoptotic and antineoplastic
activities. Upon oral administration, Bcl-2/Bcl-XL inhibitor LP-118 selectively targets,
binds to and inhibits the activity of Bcl-2 and Bcl-XL. This restores apoptotic processes
in tumor cells. Bcl-2 and Bcl-XL, Bcl-2 family proteins overexpressed in many cancers,
play important roles in the negative regulation of apoptosis. Their expression is
associated with increased drug resistance and tumor cell survival.;
Molecule name : LP 118; LP-118;
NCI Metathesaurus CUI : CL1778259;
Origin ID : C185878;
UMLS CUI : C5667043;
Semantic type(s)
- concept_is_in_subset
- has_target
