Preferred Label : Mucoadhesive Paclitaxel Formulation;
NCIt definition : An orally available, mucoadhesive lipid preparation consisting of paclitaxel, a compound
extracted from the Pacific yew tree Taxus brevifolia, in a formulation that is comprised
of a mixture of monoolein, tricarprylin, and Tween 80, with potential antineoplastic
activity. Upon oral administration, DHP107 forms droplets and micelles in the intestine;
these adhere to mucoepithelial cells in the gastrointestinal tract and are absorbed
through lipid-based uptake mechanisms. Upon absorption, paclitaxel binds to and stabilizes
tubulin molecules, which results in the inhibition of both microtubule depolymerization
and cell division. This agent also induces apoptosis by both binding to and blocking
the function of the apoptosis inhibitor protein B-cell Leukemia 2 (Bcl-2).The mucoadhesive
paclitaxel formulation does not contain P-glycoprotein inhibitors, the solvent cremophor
or any other toxic solvent.;
Molecule name : DHP107;
NCI Metathesaurus CUI : CL449448;
Origin ID : C107188;
UMLS CUI : C3827134;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
