Paclitaxel Injection Concentrate for Nanodispersion

Preferred Label : Paclitaxel Injection Concentrate for Nanodispersion;

NCIt synonyms : PICN;

NCIt definition : A nanoparticle-based injectable concentrate containing the water-insoluble taxane paclitaxel, with potential antineoplastic activity. Upon reconstitution and administration, paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Compared to paclitaxel alone, the nanodispersion-based formulation uses less toxic solvents and allows for administration of higher doses resulting in higher concentrations of paclitaxel at the tumor site, and an increased safety profile.;

Molecule name : SPARC1028; SPARC1210; SPARC1023;

NCI Metathesaurus CUI : CL428371;

Details

Origin ID

C96037;

UMLS CUI

C3272508;

Semantic type(s)
- Clinical Drug [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Apoptosis Regulator Bcl-2 [NCIt concept]
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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