" /> Venetoclax - CISMeF





Preferred Label : Venetoclax;

NCIt synonyms : 4-(4-((2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)benzamide;

NCIt definition : An orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia.;

UNII : N54AIC43PW;

InChIKey : LQBVNQSMGBZMKD-UHFFFAOYSA-N;

CAS number : 1257044-40-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1257044-40-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Venclexta; Venclyxto;

Molecule name : RG7601; ABT-199; GDC-0199; ABT-0199;

Codes from synonyms : 534;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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