Preferred Label : Bcl-2 Inhibitor TGRX-814;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2),
with potential pro-apoptotic and antineoplastic activities. Upon oral administration,
Bcl-2 inhibitor TGRX-814 targets, binds to and inhibits the activity of Bcl-2. This
restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers
and plays an important role in the negative regulation of apoptosis; its expression
is associated with increased drug resistance and tumor cell survival.;
Molecule name : TGRX 814; TGRX-814;
NCI Metathesaurus CUI : CL1928610;
Origin ID : C206270;
concept_is_in_subset
- has_target
