Preferred Label : Sonrotoclax;
NCIt synonyms : B-cell Lymphoma-2 Inhibitor BGB-11417; Bcl-2 Inhibitor BGB-11417;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2),
with potential pro-apoptotic and antineoplastic activities. Upon oral administration,
sonrotoclax specifically binds to and inhibits the activity of the pro-survival protein
Bcl-2. This restores apoptotic processes and inhibits cell proliferation in Bcl-2-overexpressing
tumor cells. Bcl-2, a protein that belongs to the Bcl-2 family, is overexpressed in
various tumor cell types and plays an important role in the negative regulation of
apoptosis. Its tumor expression is associated with increased drug resistance and cancer
cell survival.;
UNII : 30R67U9KYS;
CAS number : 2383086-06-2;
Molecule name : BGB 11417; BGB-11417;
NCI Metathesaurus CUI : CL1412833;
Origin ID : C175489;
UMLS CUI : C5854855;
Semantic type(s)
- concept_is_in_subset
- has_target
