Oblimersen - CISMeF

Preferred Label : Oblimersen;

NCIt synonyms : 5'-tct ccc agc gtg cgc cat;

NCIt related terms : olbimersen;

NCIt definition : A phosphorothioate antisense oligonucleotide. Targeted to the initiation codon region of the bcl-2 mRNA, oblimersen inhibits bcl-2 mRNA translation, resulting in decreased expression of the bcl-2 protein, an apoptotic inhibitor expressed in some types of cancer and linked to tumor drug resistance. This agent may enhance the efficacy of standard cytotoxic chemotherapy. (NCI04);

UNII : 85J5ZP6YSL;

CAS number : 190977-41-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 190977-41-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C172H221N62O91P17S17;

Codes from synonyms : CDR0000044355;

Details

Origin ID

C1870;

UMLS CUI

C0914297;

Automatic exact mappings (from CISMeF team)
- Oblimersen [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Oblimersen (substance) [SNOMED CT concept]
- oblimersen [MeSH concept]
- oblimersen [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing oblimersen (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Oblimersen (substance) [SNOMED CT concept]
- Product containing oblimersen (medicinal product) [SNOMED CT concept]
- oblimersen [ATC Code]
- oblimersen [MeSH concept]
- oblimersen [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- oblimersen [ATC Code]
chemical_or_drug_affects_gene_product
- Apoptosis Regulator Bcl-2 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- RNA Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_target
- Apoptosis Regulator Bcl-2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Etoposide/Oblimersen [NCIt concept]
- Carboplatin/Oblimersen/Paclitaxel [NCIt concept]
- Cisplatin/Fluorouracil/Oblimersen [NCIt concept]
- Cyclophosphamide/Dexrazoxane/Doxorubicin/Oblimersen [NCIt concept]
- Cyclophosphamide/Doxorubicin/Oblimersen/Prednisone/Rituximab/Vincristine [NCIt concept]
- Cyclophosphamide/Fludarabine/Oblimersen [NCIt concept]
- Cyclophosphamide/Oblimersen [NCIt concept]
- Cytarabine/Daunorubicin/Oblimersen [NCIt concept]
- Cytarabine/Fludarabine/Oblimersen [NCIt concept]
- Cytarabine/Oblimersen [NCIt concept]
- Dacarbazine/Oblimersen [NCIt concept]
- Dexamethasone/Oblimersen [NCIt concept]
- Dexamethasone/Oblimersen/Thalidomide [NCIt concept]
- Docetaxel/Doxorubicin/Oblimersen [NCIt concept]
- Docetaxel/Oblimersen [NCIt concept]
- Doxorubicin/Oblimersen [NCIt concept]
- Fluorouracil/Leucovorin Calcium/Oblimersen/Oxaliplatin [NCIt concept]
- Gemcitabine/Oblimersen [NCIt concept]
- Gemtuzumab Ozogamicin/Oblimersen [NCIt concept]
- Imatinib Mesylate/Oblimersen [NCIt concept]
- Interferon Alfa/Oblimersen [NCIt concept]
- Irinotecan/Oblimersen [NCIt concept]
- Oblimersen/Paclitaxel [NCIt concept]
- Oblimersen/Rituximab [NCIt concept]

Keyword's position in hierarchy(ies) :

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