" /> Oblimersen Sodium - CISMeF





Preferred Label : Oblimersen Sodium;

NCIt synonyms : G3139 BCL-2 Antisense Oligodeoxynucleotide; G3139 Antisense Oligonucleotide; Anticode G3139; Augmerosen; G3139 BCL-2 Antisense Oligonucleotide; BCL-2 Antisense/G3139; G3139 BCL-2 Antisense Oligo;

NCIt related terms : bcl-2 antisense oligodeoxynucleotide G3139; Genasense;

NCIt definition : The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It may kill cancer cells by blocking the production of a protein that makes cancer cells live longer and by making them more sensitive to anticancer drugs. It is a type of antisense oligodeoxyribonucleotide.;

UNII : SH55B0RQ9K;

CAS number : 190977-41-4;

Drug name : Genasense;

Molecule name : G-3139; G 3139;

Chemical formula : C172H204N62O91P17S17.17Na;

NSC code : 683428;

Codes from synonyms : CDR0000413948; CDR0000045613; CDR0000044539; CDR0000043971;

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31/05/2025


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