NCIt related terms : bcl-2 antisense oligodeoxynucleotide G3139; Genasense;
NCIt definition : The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation
codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2
mRNA translation, which may result in decreased expression of the Bcl-2 protein and
tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy.
The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein
(OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug
resistance.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It may kill cancer
cells by blocking the production of a protein that makes cancer cells live longer
and by making them more sensitive to anticancer drugs. It is a type of antisense oligodeoxyribonucleotide.;
UNII : SH55B0RQ9K;
CAS number : 190977-41-4;
Drug name : Genasense;
Molecule name : G-3139; G 3139;
Chemical formula : C172H204N62O91P17S17.17Na;
NSC code : 683428;
Codes from synonyms : CDR0000413948; CDR0000045613; CDR0000044539; CDR0000043971;