Preferred Label : Paclitaxel;
NCIt synonyms : 5Beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one, 4,10-Diacetate
2-Benzoate 13-Ester with (2R,3S)-N-Benzoyl-3-phenylisoserine; [2aR-[2a Alpha,4beta,4a beta,6beta,9alpha(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b
alpha]]-beta-(benzoylamino)-alpha-hydroxybenzene-propanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1a,33,4,-41,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-41,8,-12,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl
Ester; Taxol;
NCIt definition : A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic
activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules,
thereby resulting in the inhibition of cell division. This agent also induces apoptosis
by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell
Leukemia 2). (NCI04);
Alternative definition : NCI-GLOSS: A drug used to treat breast cancer, ovarian cancer, and AIDS-related Kaposi
sarcoma. It is also used together with another drug to treat non-small cell lung cancer.
Paclitaxel is also being studied in the treatment of other types of cancer. It blocks
cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic
agent.;
UNII : P88XT4IS4D;
InChIKey : RCINICONZNJXQF-MZXODVADSA-N;
CAS number : 33069-62-4;
Drug name : Anzatax; Praxel; Taxol Konzentrat; Bristaxol; Asotax;
Chemical formula : C47H51NO14;
NSC code : 125973; 673089;
ChEBI ID : CHEBI:45863;
Codes from synonyms : NSC0125973; 20474; CDR0000507554; CDR0000045258; 379;
Origin ID : C1411;
UMLS CUI : C0144576;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
https://www.has-sante.fr/jcms/p_3463328/fr/passeo-18-lux
2023
France
health technology assessment
paclitaxel
tympanites
paclitaxel
flatulence
Luxembourg
Paclitaxel
Balloon Device
Pegylated Paclitaxel
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https://www.has-sante.fr/jcms/p_3477470/fr/restore-deb
2023
France
health technology assessment
Pet is as Active as it Has Been
Paclitaxel
Balloon Device
Active Control
Release Determination
Diepoxybutane
flatulence
Patient Discharge
Pegylated Paclitaxel
Active State
paclitaxel
Release
Active License
tympanites
paclitaxel
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https://pgtmsite.files.wordpress.com/2024/01/paclitaxel_abraxane_seinmetastatique_20071108.pdf
2007
Canada
drug information
breast cancer
paclitaxel
Paclitaxel
Metastatic Malignant Neoplasm in the Breast
breast neoplasms
paclitaxel
Pegylated Paclitaxel
neoplasm, malignant
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