Preferred Label : R-(-)-Gossypol Acetic Acid;
NCIt synonyms : (-)-Gossypol Acetic Acid; (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-,
(2R)-, compd. with acetic acid (1:1); R-Gossypol Acetic Acid;
NCIt related terms : GOSSYPOL ACETIC ACID, (R)-;
NCIt definition : The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid
with potential antineoplastic activity. As a BH3 mimetic, R-(-)-gossypol binds to
the hydrophobic surface binding groove BH3 of the anti-apoptotic proteins Bcl-2 and
Bcl-xL, blocking their heterodimerization with pro-apoptotic members of the Bcl-2
family of proteins such as Bad, Bid, and Bim; this may result in the inhibition of
tumor cell proliferation and the induction of tumor cell apoptosis. Racemic gossypol
is a polyphenolic compound isolated from cottonseed.;
UNII : U9GNI6VT5N;
InChIKey : NIOHNDKHQHVLKA-UHFFFAOYSA-N;
CAS number : 866541-93-7;
Molecule name : AT-101; AT 101;
Chemical formula : C30H30O8.C2H4O2;
Origin ID : C78348;
UMLS CUI : C2698930;
See also inter- (CISMeF)
- Semantic type(s)
- concept_is_in_subset
- has_target
