Preferred Label : Bcl-2 Inhibitor BGB-21447;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2),
with potential pro-apoptotic and antineoplastic activities. Upon oral administration,
Bcl-2 inhibitor BGB-21447 targets, binds to and inhibits the activity of Bcl-2. This
restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers
and plays an important role in the negative regulation of apoptosis; its expression
is associated with increased drug resistance and tumor cell survival.;
Molecule name : BGB-21447; BGB 21447;
Origin ID : C213177;
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