Preferred Label : PEOX-based Polymer Encapsulated Paclitaxel FID-007;
NCIt synonyms : Paclitaxel in Polyethyloxazoline Polymer; Cationic Liposome-Encapsulated Paclitaxel; Nanoencapsulated Paclitaxel FID-007;
NCIt definition : A nanoparticle-based formulation composed of the poorly water-soluble paclitaxel encapsulated
within branched polymers composed of polyethyloxazoline (PEOX), with potential antineoplastic
activity. Upon injection of the PEOX-based polymer encapsulated paclitaxel FID-007,
the nanoparticles accumulate at the tumor site, due to the unique characteristics
of the tumor vasculature, while avoiding normal, healthy tissue. Once the paclitaxel
is released, it binds to tubulin inside tumor cells and inhibits the disassembly-assembly
dynamics of microtubules, resulting in cell cycle arrest and cell death. Compared
to the administration of paclitaxel alone, this formulation increases paclitaxel's
solubility and enhances its tumor tissue penetration and efficacy, while avoiding
systemic exposure, which minimizes its toxicity.;
Molecule name : FID-007; FID 007;
NCI Metathesaurus CUI : CL551158;
Origin ID : C148635;
UMLS CUI : C4725176;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
