Prion Pathway - CISMeF

Preferred Label : Prion Pathway;

Alternative definition : BIOCARTA: Transmissible spongiform encephalopathy (TSE) is thought to result from the structural conversion of cellular prion protein, PrP(C), into a misfolded oligomeric form, PrP(Sc). PrP is a cell membrane GPI anchored glycoprotein that is expressed in most tissues and in high levels in the nervous system. Some likely cellular functions of PrP are (1) cell protection against oxidative stress, (2) induction of neuronal cell adhesion, neurite extension and maintenance, and (3) neuroprotective signaling through a cAMP/PKA-dependent pathway. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_prionPathway;

Details

Origin ID

C39201;

UMLS CUI

C1514452;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- 78 kDa Glucose-Regulated Protein [NCIt concept]
- Amyloid-Like Protein 1 [NCIt concept]
- Apoptosis Regulator Bcl-2 [NCIt concept]
- DnaJ Homolog Subfamily B Member 6 [NCIt concept]
- Lipopolysaccharide-Binding Protein [NCIt concept]
pathway_has_gene_element
- APLP1 wt Allele [NCIt concept]
- BCL2 wt Allele [NCIt concept]
- DNAJB6 wt Allele [NCIt concept]
- HSPA5 wt Allele [NCIt concept]
- LBP wt Allele [NCIt concept]
- RPSA wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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