78 kDa Glucose-Regulated Protein

Preferred Label : 78 kDa Glucose-Regulated Protein;

NCIt synonyms : GRP 78 Protein; Heat Shock 70 kDa Protein 5; Immunoglobulin Heavy Chain Binding Protein; Immunoglobulin Heavy Chain-Binding Protein; BiP Protein; Endoplasmic Reticulum Lumenal Ca(2 )-Binding Protein grp78; BiP; GRP78; HSPA5; GRP78 Protein;

NCIt definition : 78 kDa glucose-regulated protein (654 aa, 72kDa) is encoded by the human HSPA5 gene. The protein is intracellularly localized in the endoplasmic reticulum lumen, and plays a role in the assembly of multimeric protein complexes inside the organelle. In addition, the protein is thought to function as a pro-survival protein, or an inhibitor of apoptosis.;

Details

Origin ID

C48836;

UMLS CUI

C4759837;

OMIM relation
- Heat-shock 70-kd protein 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Endoplasmic Reticulum Chaperone BiP [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Chaperone Protein Gene [NCIt concept]
- HSPA5 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
- Stress-Induced Protein [NCIt concept]
gene_product_is_element_in_pathway
- Antigen Processing and Presentation Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- Prion Pathway [NCIt concept]
- Protein Export Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Heat-Shock Response [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Protein Folding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Unfolded Protein Response [NCIt concept]
is_target
- Flexible Heteroarotinoid Sulfur Heteroarotinoid A2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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