Preferred Label : Flexible Heteroarotinoid Sulfur Heteroarotinoid A2;
NCIt synonyms : Flex-Het SHetA2;
NCIt related terms : SHETA-2;
NCIt definition : An orally bioavailable, synthetic flexible heteroarotinoid (Flex-Het), with antineoplastic
activity. Upon oral administration, Flex-Het sulfur heteroarotinoid A2 (SHetA2) binds
to the three related heat shock protein A (HSPA) chaperone proteins HSPA5 (78-kDa
glucose-regulated protein; Grp78; BiP), HSPA8 (Hsc70) and HSPA9 (mortalin), and disrupts
their binding to client proteins. This may induce G1 cell cycle arrest and apoptosis,
and inhibit tumor cell growth, migration and invasion. Grp78, hsc70, and mortalin
play important roles in ensuring the proper folding, function, and cellular localization
of their client proteins, which are important for cell survival; they are mutated
in certain cancer types.;
UNII : S886C92NJ7;
CAS number : 361483-66-1;
Molecule name : SHetA2;
NCI Metathesaurus CUI : CL1663599;
Origin ID : C181026;
UMLS CUI : C5551675;
Semantic type(s)
- concept_is_in_subset
- has_target
