Preferred Label : BCL-2 Inhibitor ICP-248;
NCIt synonyms : BCL2 Inhibitor ICP-248;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2),
with potential pro-apoptotic and antineoplastic activities. Upon oral administration,
Bcl-2 inhibitor ICP-248 targets, binds to and inhibits the activity of Bcl-2. This
restores caspase-mediated apoptosis in tumor cells. Bcl-2 is overexpressed in many
cancers and plays an important role in the negative regulation of apoptosis. Its expression
is associated with increased drug resistance and tumor cell survival.;
Molecule name : ICP-248; ICP 248;
Origin ID : C215084;
concept_is_in_subset
- has_target
