Preferred Label : Lacutoclax;
NCIt synonyms : Bcl-2 Inhibitor LP-108;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2),
with potential pro-apoptotic and antineoplastic activities. Upon oral administration,
lacutoclax targets, binds to and inhibits the activity of Bcl-2. This restores apoptotic
processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important
role in the negative regulation of apoptosis; its expression is associated with increased
drug resistance and tumor cell survival.;
UNII : PMG5245L91;
CAS number : 2291166-56-6;
Molecule name : LP 108; LP-108;
NCI Metathesaurus CUI : CL1922240;
Origin ID : C203075;
UMLS CUI : C5907992;
Semantic type(s)
- concept_is_in_subset
- has_target
