B-cell cll/lymphoma 2

Preferred Label : B-cell cll/lymphoma 2;

Symbol : BCL2;

CISMeF acronym : BCL2;

Type : Gene and phenotype, combined;

Alternative titles and symbols : Oncogene b-cell leukemia 2;

Included titles and symbols : Leukemia/lymphoma, b-cell, 2;

Inheritance : Somatic mutation;

Molecular basis : BCL2 gene on chromosome 18q21 is juxtaposed to IGH gene at 14q32, resulting chimeric BCL2-IGH mRNA is expressed blocking apoptosis;

Neoplasia : Follicular non-Hodgkin lymphoma;

Laboratory abnormalities : Translocation between 18q21 and 14q32; Detection by RT-PCR and Southern blot analysis for primary diagnosis and follow up for residual disease;

Prefixed ID : 151430;

Details

Origin ID

151430;

UMLS CUI

C0376515;

Automatic exact mappings (from CISMeF team)
- BCL2 [LOINC component]
- BCL2 apoptosis regulator [HGNC gene]
- BCL2 gene [LOINC component]
- genes, bcl-2 [MeSH Descriptor]
- genes, bcl-2 [MeSH concept]
Currated CISMeF NLP mapping
- BCL2 apoptosis regulator [ORDO Gene]
DO Cross reference
- follicular lymphoma [DO Concept]
False automatic mappings
- Apoptosis Regulator Bcl-2 [NCIt concept]
- BCL2 Gene [NCIt concept]
- BCL2 wt Allele [NCIt concept]
HPO term(s)
- B-cell lymphoma [HPO term]
- Non-Hodgkin lymphoma [HPO term]
- Somatic mutation [HPO term]
NCIt concept(s)
- Apoptosis Regulator Bcl-2 [NCIt concept]
- BCL2 Gene [NCIt concept]
- BCL2 wt Allele [NCIt concept]
ORDO concept(s)
- BCL2 apoptosis regulator [ORDO Gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- BCL2 [LOINC component]
- BCL2 Gene [NCIt concept]
- BCL2 apoptosis regulator [ORDO Gene]
- BCL2 apoptosis regulator [HGNC gene]
- BCL2 gene [LOINC component]
- genes, bcl-2 [MeSH Descriptor]
- genes, bcl-2 [MeSH concept]

Keyword's position in hierarchy(ies) :

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