NCIt definition : A microparticle-based suspension containing the water-insoluble taxane paclitaxel,
with potential antineoplastic activity. Upon intraperitoneal administration of paclitaxel-loaded
tumor penetrating microparticles (TPM), the microparticles may adhere to tumor cells,
and paclitaxel binds to and stabilizes tubulin molecules, which results in the inhibition
of both microtubule depolymerization and cell division. Paclitaxel also induces apoptosis
by both binding to and blocking the function of the apoptosis inhibitor protein B-cell
Leukemia 2 (Bcl-2).;
Semantic type(s)