Preferred Label : BH1 Domain;
NCIt synonyms : BCL-2 Homology 1 Domain;
NCIt definition : Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4)
Domains are critical to protein apoptotic function and the protein ability to interact/dimerize
with other family members or regulatory proteins. BH1 contains predominantly hydrophobic
residues. BCL-2 family proteins dimerize among pro- and anti-apoptotic class family
members. BCL-2 homodimerization appears to involve head-to-tail interaction of N-terminal
BH4 resides with more distal BH1, BH2, and BH3 regions. BCL-2/BAX heterodimerization
appears to involve tail-to-tail interaction of the BCL-2 BH1, BH2, and BH3 regions
and the BAX BH3 domain region. BCL-2 may suppress cell death partly by binding to
BAX via the BH3 domain preventing BAX homodimer formation. (NCI);
Origin ID : C13912;
UMLS CUI : C1511010;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
