Bcl-2-Like Protein 2

Preferred Label : Bcl-2-Like Protein 2;

NCIt synonyms : BCLW; BCL2-Related 2 Protein; BCL-W; BCL2 Like 2; KIAA0271; BCL2-Like 2; BCL2L2; Bcl2-L-2; Apoptosis Regulator BCL-W; BCL2L2 Protein; BCL2-Related-2 Protein;

NCIt definition : Bcl-2-like protein 2 (193 aa, 21 kDa) is encoded by the human BCL2L2 gene. This protein plays a role the regulation of apoptosis.;

NCIt note : This protein is a member of the BCL-2 protein family. Expression of this protein in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. (from RefSeq Summary);

Details

Origin ID

C21197;

UMLS CUI

C1332395;

OMIM relation
- Bcl2-like 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BCL2L2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_expressed_in_tissue
- Lymphoid Tissue [NCIt concept]
- Myeloid Cell [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Inhibitor [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- BCL-2 Family Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- BH1 Domain [NCIt concept]
- BH2 Domain [NCIt concept]
- BH4 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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