Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1

Preferred Label : Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1;

NCIt synonyms : Myeloid Cell Leukemia Sequence 1; Bcl-2-Like Protein 3; MCL1; MCL-1 Protein; Bcl2-L-3; Bcl-2-Related Protein EAT/mcl1; mcl1/EAT;

NCIt definition : Induced myeloid leukemia cell differentiation protein Mcl-1 (350 aa, 37 kDa) is encoded by the human MCL1 gene. This protein is involved in the modulation of cell viability.;

NCIt note : Is a 37 kDa protein that expressed in many types of long-lived cells. Mcl-1 protein is found in mitochondrial and other membranes also. Mcl-1 appears to function as a repressor of apoptotic cell death. It interacts with Bax, a protein promoting cell death. Overproduction of Mcl-1 can delay cell death by apoptosis associated with growth factor withdrawal, overexpression of the myc oncogene, or treatment with cytotoxic agents.;

Details

Origin ID

C17688;

UMLS CUI

C0215343;

Automatic exact mappings (from CISMeF team)
- Myeloid cell leukemia sequence 1 [OMIM gene]
- myeloid cell leukemia sequence 1 protein [MeSH Descriptor]
- myeloid cell leukemia sequence 1 protein [MeSH concept]
OMIM relation
- Myeloid cell leukemia sequence 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MCL1 protein, human [MeSH Supplementary Concept]
- MCL1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- MCL1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_expressed_in_tissue
- Mitochondrion [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Inhibitor [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- BCL-2 Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- BH1 Domain [NCIt concept]
- BH2 Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
is_target
- MCL-1 Inhibitor ABBV-467 [NCIt concept]
- MCL1 Inhibitor GS-9716 [NCIt concept]
- Mcl-1 Inhibitor AZD5991 [NCIt concept]
- Mcl-1 Inhibitor MIK665 [NCIt concept]
- Murizatoclax [NCIt concept]
- Myeloid Cell Leukemia 1 Inhibitor PRT1419 [NCIt concept]
- Tapotoclax [NCIt concept]

Keyword's position in hierarchy(ies) :

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