Preferred Label : Murizatoclax;
NCIt synonyms : Myeloid Cell Leukemia 1 Inhibitor AMG 397; MCL-1 inhibitor AMG 397;
NCIt definition : An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell
leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities.
Upon administration, MCL-1 inhibitor AMG 397 targets and binds to Mcl-1, thereby preventing
the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes
apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging
to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells
and promotes tumor cell survival.;
UNII : BO0V7196L2;
InChIKey : BJTFTQIBRVBSBH-VCQPVEJUSA-N;
CAS number : 2245848-05-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2245848-05-7
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G-SRS /a ;
Molecule name : AMG-397; AMG 397;
NCI Metathesaurus CUI : CL935903;
Origin ID : C156740;
UMLS CUI : C5418261;
Semantic type(s)
- concept_is_in_subset
- has_target
