Mcl-1 Inhibitor AZD5991

Preferred Label : Mcl-1 Inhibitor AZD5991;

NCIt synonyms : MCL1 Inhibitor AZD5991;

NCIt related terms : AZD-5991;

NCIt definition : An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, AZD5991 binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins, and promoting apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.;

UNII : E3T5XXY9HX;

CAS number : 2143010-83-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2143010-83-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AZD-5991;

NCI Metathesaurus CUI : CL524956;

Details

Origin ID

C137989;

UMLS CUI

C4527306;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AZD5991 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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