Preferred Label : MCL-1 Inhibitor ABBV-467;
NCIt synonyms : Myeloid Cell Leukemia-1 Inhibitor ABBV-467;
NCIt definition : An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell
leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities.
Upon administration, MCL-1 inhibitor ABBV-467 targets and binds to Mcl-1, thereby
preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins.
This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein
belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer
cells and promotes tumor cell survival.;
Molecule name : ABBV-467; ABBV 467;
NCI Metathesaurus CUI : CL1411952;
Origin ID : C174400;
UMLS CUI : C5418085;
Semantic type(s)
- concept_is_in_subset
- has_target
