MCL-1 Inhibitor ABBV-467

Preferred Label : MCL-1 Inhibitor ABBV-467;

NCIt synonyms : Myeloid Cell Leukemia-1 Inhibitor ABBV-467;

NCIt related terms : ABBV-467;

NCIt definition : An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MCL-1 inhibitor ABBV-467 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival.;

UNII : E1C0J49GTW;

Molecule name : ABBV-467; ABBV 467;

NCI Metathesaurus CUI : CL1411952;

Details

Origin ID

C174400;

UMLS CUI

C5418085;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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