Preferred Label : MCL1 Inhibitor GS-9716;
NCIt synonyms : Myeloid Cell Leukemia 1 Inhibitor GS-9716; Mcl-1 Inhibitor GS-9716;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein myeloid cell leukemia
1 (MCL1; induced myeloid leukemia cell differentiation protein; myeloid cell leukemia-1;
Mcl-1; Bcl2-L-3), with potential antineoplastic activity. Upon oral administration,
MCL1 inhibitor GS-9716 targets and binds to MCL1. This prevents the binding of MCL1
to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of
cells overexpressing MCL1. MCL1, an anti-apoptotic protein belonging to the Bcl-2
family of proteins, is upregulated in cancer cells and promotes tumor cell survival.;
Molecule name : GS-9716; GS 9716;
NCI Metathesaurus CUI : CL1770939;
Origin ID : C182614;
UMLS CUI : C5666889;
Semantic type(s)
- concept_is_in_subset
- has_target
