Mitochondrion - CISMeF

Preferred Label : Mitochondrion;

NCIt synonyms : Mitochondrial;

NCIt related terms : Mitochondria;

NCIt definition : Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Mitochondria contain distinctive ribosomes, transfer RNAs, amino acyl t-RNA synthetases, and elongation and termination factors. Mitochondria depend upon genes within the nucleus for many essential messenger RNAs. Mitochondria consist of two sets of membranes, a smooth continuous outer coat and an inner membrane arranged in tubules or more often in folds that form platelike double membranes (cristae). Mitochondria are the principal energy source of the cell and contains the cytochrome enzymes of terminal electron transport and the enzymes of the citric acid cycle, fatty acid oxidation, and oxidative phosphorylation. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP.;

Alternative definition : NCI-GLOSS: Small structures in a cell that are found in the cytoplasm (fluid that surrounds the cell nucleus). Mitochondria make most of the energy for the cell and have their own genetic material that is different from the genetic material found in the nucleus. Many diseases are caused by mutations (changes) in the DNA of mitochondria. Mitochondria are cell organelles.;

Codes from synonyms : CDR0000044060;

Details

Origin ID

C13258;

UMLS CUI

C0026237;

Anatomic structure is physical part of
- Cell [NCIt concept]
Associated anatomy of gene products
- 2'-5'-Oligoadenylate Synthase 1 [NCIt concept]
- 39S Ribosomal Protein L45, Mitochondrial [NCIt concept]
- 6-Pyruvoyl Tetrahydrobiopterin Synthase [NCIt concept]
- A-Kinase Anchor Protein 10, Mitochondrial [NCIt concept]
- ATP-Binding Cassette Sub-Family B Member 6, Mitochondrial [NCIt concept]
- ATP-Binding Cassette Sub-Family C Member 8 [NCIt concept]
- ATP-Binding Cassette Sub-Family G Member 1 [NCIt concept]
- ATPase WRNIP1 [NCIt concept]
- Acyl-Coenzyme A Thioesterase THEM4 [NCIt concept]
- Alanine-tRNA Ligase, Mitochondrial [NCIt concept]
- Alpha-Methylacyl-CoA Racemase [NCIt concept]
- Aspartate-tRNA Ligase, Mitochondrial [NCIt concept]
- Atypical Kinase COQ8B, Mitochondrial [NCIt concept]
- BCL2/Adenovirus E1B 19 kDa Protein-Interacting Protein 3-Like [NCIt concept]
- Bcl-2-Binding Component 3 [NCIt concept]
- Bcl-2-Like Protein 10 [NCIt concept]
- Bcl-2-Like Protein 11 [NCIt concept]
- Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, Mitochondrial [NCIt concept]
- Biotin-Protein Ligase [NCIt concept]
- CASP8-Associated Protein 2 [NCIt concept]
- COX Assembly Mitochondrial Protein 2 Homolog [NCIt concept]
- CYFIP-Related Rac1 Interactor B [NCIt concept]
- Chloride Intracellular Channel Protein 4 [NCIt concept]
- Choline Transporter-Like Protein 1 [NCIt concept]
- Cysteine-tRNA Ligase, Mitochondrial [NCIt concept]
- Cytochrome C Oxidase Assembly Protein COX11, Mitochondrial [NCIt concept]
- Cytochrome C Oxidase Subunit 1 [NCIt concept]
- Cytochrome C Oxidase Subunit 6A2, Mitochondrial [NCIt concept]
- Cytochrome C Oxidase Subunit 6C [NCIt concept]
- DNA Polymerase Subunit Gamma-1 [NCIt concept]
- DNA Repair Protein RAD51 Homolog 1 [NCIt concept]
- DNA-(Apurinic or Apyrimidinic Site) Lyase 2 [NCIt concept]
- Deoxyuridine 5'-Triphosphate Nucleotidohydrolase, Mitochondrial [NCIt concept]
- Dynamin-Like 120 kDa Protein, Mitochondrial [NCIt concept]
- E3 Ubiquitin-Protein Ligase CHIP [NCIt concept]
- Elongation Factor G, Mitochondrial [NCIt concept]
- Enoyl-CoA Delta Isomerase 2, Mitochondrial [NCIt concept]
- Enoyl-CoA Hydratase Domain-Containing Protein 3, Mitochondrial [NCIt concept]
- F-Box Only Protein 7 [NCIt concept]
- Flap Endonuclease 1 [NCIt concept]
- Fumarate Hydratase, Mitochondrial [NCIt concept]
- Glutaminase Liver Isoform, Mitochondrial [NCIt concept]
- Glutathione Reductase, Mitochondrial [NCIt concept]
- Glycerate Kinase [NCIt concept]
- Hexokinase-4 [NCIt concept]
- Humanin [NCIt concept]
- Interferon-Induced Protein with Tetratricopeptide Repeats 3 [NCIt concept]
- Kinesin-Like Protein KIF1B [NCIt concept]
- Kinesin-Like Protein KIF1C [NCIt concept]
- Methylmalonic Aciduria and Homocystinuria Type D Protein, Mitochondrial [NCIt concept]
- Mitochondrial Membrane Protein [NCIt concept]
- Monofunctional C1-Tetrahydrofolate Synthase, Mitochondrial [NCIt concept]
- N-Glycosylase/DNA Lyase [NCIt concept]
- NADH Dehydrogenase [Ubiquinone] Flavoprotein 1, Mitochondrial [NCIt concept]
- Pantothenate Kinase 2, Mitochondrial [NCIt concept]
- Phorbol-12-Myristate-13-Acetate-Induced Protein 1 [NCIt concept]
- Phosphofurin Acidic Cluster Sorting Protein 2 [NCIt concept]
- Protein C19orf12 [NCIt concept]
- Protein FAM72A [NCIt concept]
- Single-Stranded DNA-Binding Protein, Mitochondrial [NCIt concept]
- Succinate Dehydrogenase Assembly Factor 2, Mitochondrial [NCIt concept]
- Thioredoxin Reductase 2, Mitochondrial [NCIt concept]
- Trans-2-Enoyl-CoA Reductase, Mitochondrial [NCIt concept]
- Transcription Factor A, Mitochondrial [NCIt concept]
- UMP-CMP Kinase 2, Mitochondrial [NCIt concept]
- Uracil-DNA Glycosylase Isoform 1 [NCIt concept]
- WW Domain-Containing Oxidoreductase [NCIt concept]
- Zinc Phosphodiesterase ELAC Protein 2 [NCIt concept]
- p53-Regulated Apoptosis-Inducing Protein 1 [NCIt concept]
- tRNA Modification GTPase GTPBP3, Mitochondrial [NCIt concept]
Automatic exact mappings (from CISMeF team)
- ATP binding cassette subfamily B member 10 [HGNC gene]
- ATP synthase membrane subunit f [HGNC gene]
- Mitochondria [EDAM topic]
- Mitochondria [LOINC component]
- Mitochondrial inheritance [HPO term]
- NADH:ubiquinone oxidoreductase core subunit S1 [HGNC gene]
- NADH:ubiquinone oxidoreductase core subunit S2 [HGNC gene]
- NADH:ubiquinone oxidoreductase core subunit S3 [HGNC gene]
- NADH:ubiquinone oxidoreductase core subunit S3 [ORDO Gene]
- NADH:ubiquinone oxidoreductase core subunit S7 [HGNC gene]
- NADH:ubiquinone oxidoreductase core subunit S8 [HGNC gene]
- NADH:ubiquinone oxidoreductase core subunit V1 [HGNC gene]
- NADH:ubiquinone oxidoreductase core subunit V2 [HGNC gene]
- NADH:ubiquinone oxidoreductase subunit AB1 [HGNC gene]
- NADH:ubiquinone oxidoreductase subunit S6 [HGNC gene]
- NOP2/Sun RNA methyltransferase 3 [HGNC gene]
- OPA1 mitochondrial dynamin like GTPase [HGNC gene]
- TAM41 mitochondrial translocator assembly and maintenance homolog [HGNC gene]
- abhydrolase domain containing 10, depalmitoylase [HGNC gene]
- aconitase 2 [HGNC gene]
- alanyl-tRNA synthetase 2, mitochondrial [HGNC gene]
- aspartyl-tRNA synthetase 2, mitochondrial [HGNC gene]
- branched chain keto acid dehydrogenase E1 subunit beta [HGNC gene]
- cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 [HGNC gene]
- dihydrolipoamide branched chain transacylase E2 [HGNC gene]
- glutamyl-tRNA synthetase 2, mitochondrial [HGNC gene]
- glycerol-3-phosphate acyltransferase, mitochondrial [HGNC gene]
- heat shock protein family A (Hsp70) member 9 [HGNC gene]
- isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [HGNC gene]
- isoleucyl-tRNA synthetase 2, mitochondrial [HGNC gene]
- lactamase beta [HGNC gene]
- leucyl-tRNA synthetase 2, mitochondrial [HGNC gene]
- lipoic acid synthetase [HGNC gene]
- malic enzyme 2 [HGNC gene]
- methionyl-tRNA synthetase 2, mitochondrial [HGNC gene]
- methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [HGNC gene]
- mitochondrial ribosomal protein L10 [HGNC gene]
- mitochondrial ribosomal protein L36 [HGNC gene]
- mitochondrial ribosomal protein L44 [HGNC gene]
- mitochondrial ribosomal protein S17 [HGNC gene]
- mitochondrial ribosomal protein S9 [HGNC gene]
- mitochondrion [OBI concept]
- phenylalanyl-tRNA synthetase 2, mitochondrial [HGNC gene]
- pitrilysin metallopeptidase 1 [HGNC gene]
- pyruvate dehydrogenase E1 subunit alpha 1 [HGNC gene]
- seryl-tRNA synthetase 2, mitochondrial [HGNC gene]
- tetratricopeptide repeat domain 19 [HGNC gene]
- threonyl-tRNA synthetase 2, mitochondrial [HGNC gene]
- transcription factor B1, mitochondrial [HGNC gene]
- tryptophanyl tRNA synthetase 2, mitochondrial [HGNC gene]
- tyrosyl-tRNA synthetase 2 [HGNC gene]
- valyl-tRNA synthetase 2, mitochondrial [HGNC gene]
CISMeF manual mappings
- Mitochondria [OMIConto structure]
Contains anatomical structure(s)
- Inner Mitochondrial Membrane [NCIt concept]
- Intermembrane Space of the Mitochondrion [NCIt concept]
- Membrane of Crista [NCIt concept]
- Mitochondrial Matrix [NCIt concept]
- Mitochondrial Membrane [NCIt concept]
- Outer Mitochondrial Membrane [NCIt concept]
See also
- Mitochondria databases [OMIConto index]
Semantic type(s)
- Cell Component [UMLS semantic type]
anatomic_structure_has_location
- Cytoplasm [NCIt concept]
cell_type_or_tissue_affected_by_chemical_or_drug
- Arsenic Trioxide [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
is_location_of_biological_process
- Cell Death Signaling Process [NCIt concept]
- Cell Respiration [NCIt concept]
tissue_is_expression_site_of_gene_product
- Bcl-2-Like Protein 1 [NCIt concept]
- Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 [NCIt concept]

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