Bcl-2-Binding Component 3

Preferred Label : Bcl-2-Binding Component 3;

NCIt synonyms : PUMA; JFY-1; p53 Up-Regulated Modulator of Apoptosis; BBC3 Protein;

NCIt definition : Bcl-2-binding component 3 (193 aa, 21 kDa) is encoded by the human BBC3 gene. This protein plays a role in the regulation of apoptosis.;

NCIt note : Many p53 pathway agonists, which are being developed to treat cancer, are modeled against Bcl-2-binding component 3.;

Details

Origin ID

C91774;

UMLS CUI

C2984551;

Currated CISMeF NLP mapping
- puma [MeSH Descriptor]
- puma [MeSH concept]
OMIM relation
- Bcl2-binding component 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BBC3 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrion [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Huntington's Disease Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Caspase Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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