Biotin-Protein Ligase

Preferred Label : Biotin-Protein Ligase;

NCIt synonyms : HLCS; Biotin--Protein Ligase; HCS; EC 6.3.4.-; Biotin Apo-Protein Ligase; Holocarboxylase Synthetase;

NCIt definition : Biotin-protein ligase (726 aa, 81 kDa) is encoded by the human HLCS gene. This protein plays a role in the biotinylation of protein substrates.;

NCIt note : Biotin-protein ligase exhibits four types of enzymatic activity: biotin-[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9), biotin-[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (holocarboxylase synthetase (HCS); EC 6.3.4.10), biotin-[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11) and biotin-[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15). (UniProt);

NCI Metathesaurus CUI : CL1799238;

Details

Origin ID

C190519;

UMLS CUI

C5780721;

OMIM relation
- Holocarboxylase synthetase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HLCS Gene [NCIt concept]
- Ligase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Mitochondrion [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Biotin Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Post-Translational Modification [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients