Serine Hydroxymethyltransferase 2, Mitochondrial

Preferred Label : Serine Hydroxymethyltransferase 2, Mitochondrial;

NCIt synonyms : Serine Methylase; SHMT2; EC 2.1.2.1; SHMT; Glycine Hydroxymethyltransferase; Serine Hydroxymethyltransferase 2;

NCIt definition : Serine hydroxymethyltransferase, mitochondrial (504 aa, 56 kDa) is encoded by the human SHMT2 gene. This protein is involved in mitochondrial translation and catalyzing the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate.;

Détails

Origin ID

C215060;

OMIM relation
- Serine hydroxymethyltransferase, mitochondrial [OMIM gene]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- SHMT2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrion [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glycine, Serine and Threonine Metabolism Pathway [NCIt concept]
- Glyoxylate and Dicarboxylate Metabolism Pathway [NCIt concept]
- One Carbon Pool by Folate Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Amino Acid Biosynthesis [NCIt concept]
- Folic Acid Metabolic Process [NCIt concept]
- Methylation [NCIt concept]
- Nucleotide Biosynthesis Process [NCIt concept]

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