E3 Ubiquitin-Protein Ligase CHIP

Preferred Label : E3 Ubiquitin-Protein Ligase CHIP;

NCIt synonyms : C Terminus of Hsp70-Interacting Protein BIA1; STIP1 Homologous and U Box-Containing Protein 1; STIP1 Homologous and U-Box Containing Protein 1; CLL-Associated Antigen KW-8; EC 2.3.2.27; RING-Type E3 Ubiquitin Transferase CHIP; STUB1; STIP1 Homology and U Box-Containing Protein 1; STIP1 Homology and U-Box Containing Protein 1; Antigen NY-CO-7; Carboxy Terminus of Hsp70-Interacting Protein;

NCIt definition : E3 ubiquitin-protein ligase CHIP (303 aa, 35 kDa) is encoded by the human STUB1 gene. This protein plays a role in the ubiquitination of misfolded chaperone proteins, which promotes the degradation of those misfolded substrates.;

Détails

Origin ID

C208036;

OMIM relation
- Stip1 homologous and u box-containing protein 1 [OMIM gene]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- STUB1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Endoplasmic Reticulum [NCIt concept]
- Mitochondrion [NCIt concept]
- Nucleoplasm [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Tetratricopeptide Repeat [NCIt concept]
gene_product_is_element_in_pathway
- Alpha-Synuclein Signaling Pathway [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Heat-Shock Response [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]
- Unfolded Protein Response [NCIt concept]

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