" /> Bcl-2-Like Protein 11 - CISMeF





Preferred Label : Bcl-2-Like Protein 11;

NCIt synonyms : BCL2L11; BIM; BIML; Bcl-2 Interacting Protein Bim; Bcl2-L-11; BOD; BAM; BIMEL; BCL2-Related Protein 11; Bcl2-Interacting Mediator of Cell Death; BimMEL; BCL2-Related Protein-11;

NCIt definition : Bcl-2-like protein 11 (198 aa, 22 kDa) is encoded by the human BCL2L11 gene. This protein is involved in the induction of apoptosis.;

NCIt note : This protein belongs to the BCL-2 protein family. It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests the roles of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. (from RefSeq Summary); Bcl-2-like protein 11 has several isoforms that are able to induce apoptosis with different potencies.;

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12/05/2024


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