Flap Endonuclease 1

Preferred Label : Flap Endonuclease 1;

NCIt synonyms : FEN-1; EC 3.1.-.-; hFEN-1; Flap Structure-Specific Endonuclease 1; MF1; DNase IV; Maturation Factor 1;

NCIt definition : Flap endonuclease 1 (380 aa, 43 kDa) is encoded by the human FEN1 gene. This protein is involved in both the removal of 5' overhangs during DNA repair and the processing of the 5' end of Okazaki fragments during DNA replication.;

Details

Origin ID

C98122;

UMLS CUI

C0525494;

Automatic exact mappings (from CISMeF team)
- Flap structure-specific endonuclease 1 [OMIM gene]
- flap Endonuclease-1 [MeSH concept]
- flap endonucleases [MeSH Descriptor]
- flap structure-specific endonuclease 1 [HGNC gene]
OMIM relation
- Flap structure-specific endonuclease 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- FEN1 protein, human [MeSH Supplementary Concept]
- FEN1 protein, human [MeSH concept]
- flap Endonuclease-1 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- FEN1 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrion [NCIt concept]
- Nucleoplasm [NCIt concept]
gene_product_has_biochemical_function
- 5'-3' Exonuclease [NCIt concept]
- DNA Repair Endonuclease [NCIt concept]
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Base Excision Repair Pathway [NCIt concept]
- DNA Replication Pathway [NCIt concept]
- Non-Homologous End-Joining Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Base Excision Repair [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Replication [NCIt concept]
- Double Strand Break Repair [NCIt concept]
- Hydrolysis [NCIt concept]
- Telomere Recombination [NCIt concept]

Keyword's position in hierarchy(ies) :

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