ATP-Binding Cassette Sub-Family C Member 8

Preferred Label : ATP-Binding Cassette Sub-Family C Member 8;

NCIt synonyms : ATP Binding Cassette Subfamily C Member 8; ABCC8; ATP-Binding Cassette Transporter Sub-Family C Member 8; Sulfonylurea Receptor 1; SUR; SUR1;

NCIt definition : ATP-binding cassette sub-family C member 8 (1581 aa, 177 kDa) is encoded by the human ABCC8 gene. This protein is involved in ATPase-coupled transmembrane transport of potassium ions and insulin.;

NCIt note : ATP-binding cassette sub-family C member 8 is expressed in pancreatic beta-cell and is the target for sulfonylurea-based antidiabetic therapeutics.;

NCI Metathesaurus CUI : CL359373;

Details

Origin ID

C191885;

UMLS CUI

C3711621;

OMIM relation
- Atp-binding cassette, subfamily C, member 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ABCC8 protein, human [MeSH Supplementary Concept]
- ABCC8 protein, human [MeSH concept]
gene_encodes_gene_product
- ABCC8 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Mitochondrion [NCIt concept]
- Plasma Membrane [NCIt concept]
- Secretory Vesicle [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- Permease [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- ABC Transporter Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Drug Efflux [NCIt concept]
- Homeostatic Process [NCIt concept]
- Hormone Activity Induction [NCIt concept]
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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