ABC Transporter Pathway

Preferred Label : ABC Transporter Pathway;

NCIt synonyms : ATP-Binding Cassette Transporter Pathway;

NCIt related terms : ABC transporters;

Alternative definition : KEGG: The ATP-binding cassette (ABC) transporters form one of the largest known protein families and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).;

KEGG ID : hsa02010;

Details

Origin ID

C91509;

UMLS CUI

C2984318;

Automatic exact mappings (from CISMeF team)
- ATP-Binding cassette transporters [MeSH Descriptor]
Semantic type(s)
- Functional Concept [UMLS semantic type]
UMLS correspondences (same concept)
- ABC-type transporter activity [GO term]
- obsolete ABC-type efflux permease activity [GO term]
- obsolete ABC-type efflux porter activity [GO term]
- obsolete ABC-type uptake permease activity [GO term]
has_gene_product_element
- ATP-Binding Cassette Sub-Family A Member 2 [NCIt concept]
- ATP-Binding Cassette Sub-Family B Member 5 [NCIt concept]
- ATP-Binding Cassette Sub-Family B Member 6, Mitochondrial [NCIt concept]
- ATP-Binding Cassette Sub-Family C Member 8 [NCIt concept]
- ATP-Binding Cassette Sub-Family D Member 1 [NCIt concept]
- ATP-Binding Cassette Sub-Family F Member 2 [NCIt concept]
- ATP-Binding Cassette Sub-Family G Member 1 [NCIt concept]
- Antigen Peptide Transporter 1 [NCIt concept]
- Antigen Peptide Transporter 2 [NCIt concept]
- Bile Salt Export Pump [NCIt concept]
- Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 [NCIt concept]
- Canalicular Multispecific Organic Anion Transporter 1 [NCIt concept]
- Canalicular Multispecific Organic Anion Transporter 2 [NCIt concept]
- Cholesterol Transporter ABCA5 [NCIt concept]
- Cystic Fibrosis Transmembrane Conductance Regulator [NCIt concept]
- Glucosylceramide Transporter ABCA12 [NCIt concept]
- Lysosomal Cobalamin Transporter ABCD4 [NCIt concept]
- Multidrug Resistance Protein 1 [NCIt concept]
- Multidrug Resistance-Associated Protein 1 [NCIt concept]
- Multidrug Resistance-Associated Protein 4 [NCIt concept]
- Multidrug Resistance-Associated Protein 5 [NCIt concept]
- Multidrug Resistance-Associated Protein 6 [NCIt concept]
- Phosphatidylcholine Translocator ABCB4 [NCIt concept]
- Phospholipid-Transporting ATPase ABCA1 [NCIt concept]
- Phospholipid-Transporting ATPase ABCA3 [NCIt concept]
- Phospholipid-Transporting ATPase ABCA7 [NCIt concept]
pathway_has_gene_element
- ABCA1 wt Allele [NCIt concept]
- ABCA12 wt Allele [NCIt concept]
- ABCA2 wt Allele [NCIt concept]
- ABCA3 wt Allele [NCIt concept]
- ABCA5 wt Allele [NCIt concept]
- ABCA7 wt Allele [NCIt concept]
- ABCB1 wt Allele [NCIt concept]
- ABCB11 wt Allele [NCIt concept]
- ABCB4 wt Allele [NCIt concept]
- ABCB5 wt Allele [NCIt concept]
- ABCB6 wt Allele [NCIt concept]
- ABCC1 wt Allele [NCIt concept]
- ABCC2 wt Allele [NCIt concept]
- ABCC3 wt Allele [NCIt concept]
- ABCC4 wt Allele [NCIt concept]
- ABCC5 wt Allele [NCIt concept]
- ABCC6 wt Allele [NCIt concept]
- ABCC8 wt Allele [NCIt concept]
- ABCD1 wt Allele [NCIt concept]
- ABCD4 wt Allele [NCIt concept]
- ABCF2 wt Allele [NCIt concept]
- ABCG1 wt Allele [NCIt concept]
- ABCG2 wt Allele [NCIt concept]
- CFTR wt Allele [NCIt concept]
- TAP1 wt Allele [NCIt concept]
- TAP2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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