ATP-Binding Cassette Sub-Family B Member 5

Preferred Label : ATP-Binding Cassette Sub-Family B Member 5;

NCIt synonyms : P-Glycoprotein ABCB5; ATP-Binding Cassette, Sub-Family B, Member 5; ABCB5 P-gp; ATP-Binding Cassette, Sub-Family B Member 5;

NCIt definition : ATP-binding cassette sub-family B member 5 (812 aa, 90 kDa) is encoded by the human ABCB5 gene. This protein plays a role in small molecule membrane transport and drug resistance in some melanomas.;

NCIt note : An antibody direct against this protein was able to inhibit melanoma formation in a mouse model. (Nature 2008; 451, 345-349.);

Details

Origin ID

C73557;

UMLS CUI

C2346565;

OMIM relation
- Atp-binding cassette, subfamily b, member 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ABCB5 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Multidrug Resistance Gene [NCIt concept]
- Translocase Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- Permease [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- ABC Transporter Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Drug Efflux [NCIt concept]
- Ligand Binding [NCIt concept]
- Multidrug Resistance Process [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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