Multidrug Resistance Gene

Preferred Label : Multidrug Resistance Gene;

NCIt synonyms : MDR Gene; MDR;

NCIt definition : Mammalian P-glycoproteins are encoded by the MDR gene family and belong to the ATP-binding cassette vectorial transport protein class; the CFTR chloride channel is also a family member. The human multidrug resistance 1 (MDR1) gene responds to environmental stress, including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. MDR1 and MDR2 P-glycoproteins are large apical cell membrane proteins overproduced in multidrug-resistant (MDR) cancer cells resistant to diverse hydrophobic drugs. P-glycoproteins act as pumps able to extrude drugs from cells at the cost of ATP hydrolysis. MDR is primarily due to increased drug extrusion from the resistant cell. Defense against xenobiotics may be a natural function of these P-glycoproteins.;

Details

Origin ID

C17967;

UMLS CUI

C0376623;

Automatic exact mappings (from CISMeF team)
- Multidrug-resistant bacteria (organism) [SNOMED CT concept]
- retinol dehydrogenase activity [GO term]
Currated CISMeF NLP mapping
- genes, MDR [MeSH concept]
- genes, mdr [MeSH Descriptor]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- genes, MDR [MeSH concept]
- genes, mdr [MeSH Descriptor]
gene_encodes_gene_product
- ABC Transporter [NCIt concept]
- ATP-Binding Cassette Sub-Family A Member 2 [NCIt concept]
- ATP-Binding Cassette Sub-Family B Member 5 [NCIt concept]
- ATP-Binding Cassette Sub-Family B Member 6, Mitochondrial [NCIt concept]
- ATP-Binding Cassette Sub-Family D Member 1 [NCIt concept]
- ATP-Binding Cassette Sub-Family F Member 2 [NCIt concept]
- ATP-Binding Cassette Sub-Family G Member 1 [NCIt concept]
- Antigen Peptide Transporter 1 [NCIt concept]
- Antigen Peptide Transporter 2 [NCIt concept]
- Bile Salt Export Pump [NCIt concept]
- Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 [NCIt concept]
- Canalicular Multispecific Organic Anion Transporter 1 [NCIt concept]
- Canalicular Multispecific Organic Anion Transporter 2 [NCIt concept]
- Cholesterol Transporter ABCA5 [NCIt concept]
- Cystic Fibrosis Transmembrane Conductance Regulator [NCIt concept]
- Multidrug Resistance Protein 1 [NCIt concept]
- Multidrug Resistance-Associated Protein 1 [NCIt concept]
- Multidrug Resistance-Associated Protein 4 [NCIt concept]
- Multidrug Resistance-Associated Protein 5 [NCIt concept]
- Multidrug Resistance-Associated Protein 6 [NCIt concept]
- Phosphatidylcholine Translocator ABCB4 [NCIt concept]
- Phospholipid-Transporting ATPase ABCA1 [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Drug Efflux [NCIt concept]
- Multidrug Resistance Process [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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