Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2

Preferred Label : Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2;

NCIt synonyms : Placenta-Specific ATP-Binding Cassette Transporter; BCRP1 Protein; Mitoxantrone Resistance Protein; ATP Binding Cassette Transporter G2; Placenta Specific MDR Protein; ABCG2; Breast Cancer Resistance Protein 1; Mitoxantrone-Resistance Protein; ATP Binding Cassette Transporter-G2; Breast Cancer Resistance Protein; CD338 Antigen; Mitoxantrone Resistance-Associated Protein; Urate Exporter; CDw338; BRCP; CD338; ATP-Binding Cassette Sub-Family G Member 2;

NCIt definition : Broad substrate specificity ATP-binding cassette transporter ABCG2 (655 aa, 72 kDa) is encoded by the human ABCG2 gene. This protein is involved in the transport of urate, heme, porphyrin and xenobiotics.;

NCIt note : ATP-binding cassette sub-family G member 2 has been implicated in the export of mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), daunorubicin, and doxorubicin;

Details

Origin ID

C21253;

UMLS CUI

C0761993;

OMIM relation
- Atp-binding cassette, subfamily g, member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ABCG2 protein, human [MeSH Supplementary Concept]
- ABCG2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ABCG2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Multidrug Resistance Gene [NCIt concept]
- Translocase Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Placenta [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- Permease [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- ABC Transporter Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- HIF-2-Alpha Transcription Factor Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Drug Efflux [NCIt concept]
- Ligand Binding [NCIt concept]
- Multidrug Resistance Process [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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