Multidrug Resistance Process

Preferred Label : Multidrug Resistance Process;

NCIt synonyms : Multiple Drug Resistance;

NCIt related terms : multidrug resistance; MDR;

Alternative definition : NCI-GLOSS: Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective.; CDISC: Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.;

Codes from synonyms : CDR0000045790;

Details

Origin ID

C17745;

UMLS CUI

C0242640;

Automatic exact mappings (from CISMeF team)
- Multidrug-resistant bacteria (organism) [SNOMED CT concept]
- genes, MDR [MeSH concept]
- genes, mdr [MeSH Descriptor]
- retinol dehydrogenase activity [GO term]
Currated CISMeF NLP mapping
- Multiple-drug resistance [MedDRA Preferred Term]
- drug resistance, multiple [MeSH Descriptor]
- drug resistance, multiple [MeSH concept]
Semantic type(s)
- Organism Attribute [UMLS semantic type]
UMLS correspondences (same concept)
- Multiple-drug resistance [MedDRA Preferred Term]
- drug resistance, multiple [MeSH concept]
- drug resistance, multiple [MeSH Descriptor]
biological_process_has_associated_location
- Plasma Membrane [NCIt concept]
biological_process_has_initiator_chemical_or_drug
- Pharmacologic Substance [NCIt concept]
biological_process_involves_gene_product
- ATP-Binding Cassette Sub-Family B Member 5 [NCIt concept]
- ATP-Binding Cassette Sub-Family B Member 6, Mitochondrial [NCIt concept]
- Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 [NCIt concept]
- Canalicular Multispecific Organic Anion Transporter 2 [NCIt concept]
- Glutathione S-Transferase P [NCIt concept]
- Multidrug Resistance Protein 1 [NCIt concept]
- Multidrug Resistance-Associated Protein 1 [NCIt concept]
- Multidrug Resistance-Associated Protein 6 [NCIt concept]
- Multidrug and Toxin Extrusion Protein 1 [NCIt concept]
- Multidrug and Toxin Extrusion Protein 2 [NCIt concept]
- Phosphatidylcholine Translocator ABCB4 [NCIt concept]
concept_is_in_subset
- CDISC SDTM Drug Resistance Status Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
process_includes_biological_process
- Drug Efflux [NCIt concept]
process_involves_gene
- ABCB1 2 Allele [NCIt concept]
- ABCB1 Gene [NCIt concept]
- ABCB1 wt Allele [NCIt concept]
- ABCB4 Gene [NCIt concept]
- ABCB4 wt Allele [NCIt concept]
- ABCB5 Gene [NCIt concept]
- ABCB5 wt Allele [NCIt concept]
- ABCB6 Gene [NCIt concept]
- ABCB6 wt Allele [NCIt concept]
- ABCC1 Gene [NCIt concept]
- ABCC1 wt Allele [NCIt concept]
- ABCC3 Gene [NCIt concept]
- ABCC3 wt Allele [NCIt concept]
- ABCC6 Gene [NCIt concept]
- ABCC6 wt Allele [NCIt concept]
- ABCG2 Gene [NCIt concept]
- ABCG2 wt Allele [NCIt concept]
- GSTP1 Gene [NCIt concept]
- GSTP1 wt Allele [NCIt concept]
- Multidrug Resistance Gene [NCIt concept]
- SLC47A1 Gene [NCIt concept]
- SLC47A1 wt Allele [NCIt concept]
- SLC47A2 Gene [NCIt concept]
- SLC47A2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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