ABCB5 wt Allele

Preferred Label : ABCB5 wt Allele;

NCIt synonyms : EST422562; ABCB5beta; ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 wt Allele; ABCB5alpha;

NCIt definition : Human ABCB5 wild-type allele is located in the vicinity of 7p15.3 and is approximately 108 kb in length. This allele, which encodes ATP-binding cassette sub-family B member 5 protein, is involved in the mediation of the transport of small molecules across membranes. Expression of the gene is linked to drug resistance for a subset of melanomas.;

NCIt note : The ABCB5 gene is expressed as two isoforms with products designated alpha and beta. The alpha form is a shorter construct produced by alternative splicing. (SwissProt); Depletion of the expression of the ABCB5 gene through RNA interference increases the drug sensitivity of chemotherapy resistant melanoma cells. (SwissProt);

GenBank Accession Number : U66692;

Details

Origin ID

C73556;

UMLS CUI

C2348418;

OMIM relation
- Atp-binding cassette, subfamily b, member 5 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_is_element_in_pathway
- ABC Transporter Pathway [NCIt concept]
gene_plays_role_in_process
- Drug Efflux [NCIt concept]
- Ligand Binding [NCIt concept]
- Multidrug Resistance Process [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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