Phosphatidylcholine Translocator ABCB4

Preferred Label : Phosphatidylcholine Translocator ABCB4;

NCIt synonyms : P-Glycoprotein 3; Multiple Drug Resistance 3; ATP-Binding Cassette Sub-Family B Member 4; EC 7.6.2.2; Multidrug Resistance Protein 3; EC 3.6.3.44, Formerly; ABCB4;

NCIt definition : Phosphatidylcholine translocator ABCB4 (1286 aa, 142 kDa) is encoded by the human ABCB4 gene. This protein is involved in the transport of phosphatidylcholine, organic anions and drugs.;

NCIt note : An antibody direct against this protein was able to inhibit melanoma formation in a mouse model. (Nature 2008; 451, 345-349.);

NCI Metathesaurus CUI : CL968836;

Details

Origin ID

C123864;

UMLS CUI

C1260069;

Automatic exact mappings (from CISMeF team)
- ATP binding cassette subfamily B member 4 [ORDO Gene]
- Atp-binding cassette, subfamily b, member 4 [OMIM gene]
- multidrug resistance protein 3 [MeSH concept]
- multidrug resistance protein 3 [MeSH Supplementary Concept]
OMIM relation
- Atp-binding cassette, subfamily b, member 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ABCB4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ABCB4 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Multidrug Resistance Gene [NCIt concept]
- Translocase Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- Permease [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- ABC Transporter Pathway [NCIt concept]
- Multi-Drug Resistance Factor Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Drug Efflux [NCIt concept]
- Ligand Binding [NCIt concept]
- Multidrug Resistance Process [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Phospholipid Metabolism [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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