" /> GSTP1 wt Allele - CISMeF





Preferred Label : GSTP1 wt Allele;

NCIt synonyms : GST3; GSTP1-1; FAEES3; Fatty Acid Ethyl Ester Synthase III Gene; GSTPP; GST3 Gene; DFN7; Glutathione S-Transferase Pi Gene; Fatty Acid Ethyl Ester Synthase III, Myocardial Gene; Glutathione S-Transferase, Pi Gene; Glutathione S-Transferase Pi 1 wt Allele; HEL-S-22; GSTP;

NCIt definition : Human GSTP1 wild-type allele is located within 11q13 and is approximately 3 kb in length. This allele, which encodes glutathione S-transferase Pi protein, plays a role in the conjugation of reduced glutathione with both endogenous and exogenous hydrophobic electrophilic compounds. Due to promoter hypermethylation, the GSTP1 gene is not expressed in prostatic intraepithelial neoplasia or prostatic adenocarcinomas.;

NCIt note : Allelic variants of the GSTP1 gene may confer susceptibility to several forms of cancer. The methylated form of this gene is a marker for Prostate Cancer.;

GenBank Accession Number : NM_000852;

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20/05/2024


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