Preferred Label : Multi-Drug Resistance Factor Pathway;
NCIt related terms : Multi-Drug Resistance Factors;
Alternative definition : BIOCARTA: Cancer cells resistant to a diverse set of hydrophobic drugs are known as
MDR cells (multidrug-resistant). Large membrane proteins overproduced in MDR cells,
belong to a family of transport P-glycoproteins known as ATP-binding cassette transporter
proteins (ABC-ATPases). These proteins were initially thought to affect the permeability
of cells to drugs, but they were later found to be pumps that remove drugs from cells
at the cost of ATP hydrolysis. There are seven major families of ABC(ATP-binding cassette)
proteins, two of them are shown on this pathway, MDR/TAP (Multi-Drug Resistance) and
MRP (Multi-Drug Resistance Related Proteins). Members of the MDR/TAP subfamily are
involved in multi-drug resistance as well as antigen presentation. Additional factors
involved in detoxification are the P450 cytochromes (CYPs), glutathione-S-transferase
(GST). Lack of MDR3 can cause a form of Progressive Familial Intrahepatic Cholestasis
(PFIC), a heterogeneous group of autosomal recessive liver disorders, characterized
by early onset of cholestasis that progresses to cirrhosis and liver failure before
adulthood. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_mrpPathway;
Origin ID : C91308;
UMLS CUI : C2984149;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
