Multidrug Resistance Protein 1

Preferred Label : Multidrug Resistance Protein 1;

NCIt synonyms : ABCB1; P-Glycoprotein 1; MDR1 Protein; P-Glycoprotein Transporter; Multidrug Resistance 1; CD243 Antigen; ATP-Binding Cassette Sub-Family B Member 1; P-Glycoprotein-1; EC 7.6.2.2; EC 3.6.3.44, Formerly;

NCIt related terms : p-glycoprotein;

NCIt definition : Multidrug resistance protein 1 (1280 aa, 141 kDa) is encoded by the human ABCB1 gene. This protein plays a role in both ATP-dependent transport of xenobiotics and resistance to chemotherapeutics.;

Alternative definition : NCI-GLOSS: A protein that pumps substances out of cells. Cancer cells that have too much p-glycoprotein may not be killed by anticancer drugs.;

Codes from synonyms : CDR0000643067;

Details

Origin ID

C17746;

UMLS CUI

C1738970;

OMIM relation
- Atp-binding cassette, subfamily b, member 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ABCB1 protein, human [MeSH concept]
- ABCB1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ABCB1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Multidrug Resistance Gene [NCIt concept]
- Translocase Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Valspodar [NCIt concept]
gene_product_has_associated_anatomy
- Blood-Brain Barrier [NCIt concept]
- Cellular Membrane [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- Permease [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- ABC Transporter Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Hypoxia Pathway [NCIt concept]
- Lipid Metabolism and Toxicity Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Drug Efflux [NCIt concept]
- Ligand Binding [NCIt concept]
- Multidrug Resistance Process [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]
is_target
- Patupilone [NCIt concept]
- SDZ 280-446 [NCIt concept]
- Tariquidar [NCIt concept]
- Valspodar [NCIt concept]

Keyword's position in hierarchy(ies) :

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