SDZ 280-446 - CISMeF

Preferred Label : SDZ 280-446;

NCIt synonyms : Cyclo-(pec1-meval2-val3-(O-t-Bu-measp4)-melle5-melle6-gly7-meval8-(O-Me-tyr)-L-hpa10);

NCIt definition : A novel semi-synthetic derivative of cyclosporin and a cyclodepsipeptide with chemo-sensitizing activity. SDZ 280-446 is one of the drug resistance-modifying agents that inhibit P-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activities of some drugs in drug-resistant tumor cells.;

CAS number : 129893-84-1;

Details

Origin ID

C60767;

UMLS CUI

C0141820;

Currated CISMeF NLP mapping
- SDZ 280 446 [MeSH concept]
- SDZ 280 446 [MeSH Supplementary Concept]
See also inter- (CISMeF)
- cyclo-(Pec1-MeVal2-Val3-(-O-t.Bu-MeAsp4)-Melle5-Melle6-Gly7-MeVal8-(O-Me-Tyr)-L-Hpa10) [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SDZ 280 446 [MeSH concept]
- SDZ 280 446 [MeSH Supplementary Concept]
has_target
- Multidrug Resistance Protein 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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