NCIt definition : An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively
binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport
of anticancer drugs. Inhibition of transmembrane transport may result in increased
intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity.
(NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It may help
tumor cells respond again to drugs they have become resistant (unable to respond)
to. Tariquidar is a type of multidrug resistance inhibitor and a type of P-glycoprotein
antagonist.;
UNII : J58862DTVD;
InChIKey : LGGHDPFKSSRQNS-UHFFFAOYSA-N;
CAS number : 206873-63-4;
Molecule name : XR9576;
Chemical formula : C38H38N4O6;
Codes from synonyms : CDR0000301627; CDR0000044895;