NCIt related terms : 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic Acid]cyclosporin D; PSC 833;
NCIt definition : An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance
efflux pump, thereby restoring the retention and activity of some drugs in some drug-resistant
tumor cells. This agent also induces caspase-mediated apoptosis. (NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied for its ability to prevent or overcome
the resistance of tumor cells to some anticancer drugs. It belongs to the family of
drugs called cyclosporine analogs.;