Valspodar - CISMeF

Preferred Label : Valspodar;

NCIt synonyms : Cyclo((2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl)-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-me;

NCIt related terms : 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic Acid]cyclosporin D; PSC 833;

NCIt definition : An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity of some drugs in some drug-resistant tumor cells. This agent also induces caspase-mediated apoptosis. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied for its ability to prevent or overcome the resistance of tumor cells to some anticancer drugs. It belongs to the family of drugs called cyclosporine analogs.;

UNII : Q7ZP55KF3X;

InChIKey : YJDYDFNKCBANTM-QCWCSKBGSA-N;

CAS number : 121584-18-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 121584-18-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Amdray;

Molecule name : PSC-833; SZD PSC 833; VP16;

Chemical formula : C63H111N11O12;

NSC code : 648265;

Codes from synonyms : 32019; CDR0000045396;

Details

Origin ID

C1405;

UMLS CUI

C0753474;

Automatic exact mappings (from CISMeF team)
- etoposide [MeSH Descriptor]
Currated CISMeF NLP mapping
- valspodar [MeSH concept]
- valspodar [MeSH Supplementary Concept]
Manual BTNT mappings - CISMeF
- SDZ PSC 833 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- valspodar [MeSH concept]
- valspodar [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Multidrug Resistance Protein 1 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- ABC Transporter Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Multidrug Resistance Inhibition [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Multidrug Resistance Protein 1 [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Paclitaxel/PSC 833 [NCIt concept]
- Cytarabine/Daunorubicin/Etoposide/PSC 833 [NCIt concept]
- Cytarabine/Daunorubicin/PSC 833 [NCIt concept]
- Cytarabine/Etoposide/Mitoxantrone/PSC 833 [NCIt concept]
- Dexamethasone/Doxorubicin/PSC 833/Vincristine [NCIt concept]
- Doxorubicin HCl Liposome/PSC 833 [NCIt concept]
- Doxorubicin/PSC 833 [NCIt concept]
- Etoposide/Mitoxantrone/PSC 833 [NCIt concept]
- PSC 833/Vinblastine [NCIt concept]
- Paclitaxel/PSC 833 [NCIt concept]

Keyword's position in hierarchy(ies) :

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