" /> Valspodar - CISMeF





Preferred Label : Valspodar;

NCIt synonyms : Cyclo((2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl)-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-me;

NCIt related terms : 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic Acid]cyclosporin D; PSC 833;

NCIt definition : An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity of some drugs in some drug-resistant tumor cells. This agent also induces caspase-mediated apoptosis. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied for its ability to prevent or overcome the resistance of tumor cells to some anticancer drugs. It belongs to the family of drugs called cyclosporine analogs.;

UNII : Q7ZP55KF3X;

InChIKey : YJDYDFNKCBANTM-QCWCSKBGSA-N;

CAS number : 121584-18-7;

Drug name : Amdray;

Molecule name : PSC-833; SZD PSC 833; VP16;

Chemical formula : C63H111N11O12;

NSC code : 648265;

Codes from synonyms : 32019; CDR0000045396;

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31/05/2025


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