Multidrug Resistance Inhibition

Preferred Label : Multidrug Resistance Inhibition;

NCIt definition : Multidrug Resistance Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in processes that increase the ability of cancer cells to counteract, defeat, or withstand the effects of multiple chemotherapeutic agents. Mechanisms involve decreased expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, increased topoisomerase II activity, and changes in various cellular proteins. Inhibition results in increased transport of drug into, or decreased transport out of, cells and increased effectiveness of chemotherapeutic agents.;

Details

Origin ID

C40818;

UMLS CUI

C1513739;

Semantic type(s)
- Cell Function [UMLS semantic type]
biological_process_has_associated_location
- Plasma Membrane [NCIt concept]
biological_process_has_initiator_chemical_or_drug
- Pharmacologic Substance [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- Idronoxil Suppository NOX66 [NCIt concept]
- Topoisomerase-II Inhibitor Racemic XK469 [NCIt concept]
- Valspodar [NCIt concept]

Keyword's position in hierarchy(ies) :

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