Topoisomerase-II Inhibitor Racemic XK469

Preferred Label : Topoisomerase-II Inhibitor Racemic XK469;

NCIt synonyms : XK469 Racemic; Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]-phenoxy]-, ( /-)-;

NCIt definition : The racemic form of a synthetic quinoxaline phenoxypropionic acid derivative with antineoplastic properties. XK469R selectively inhibits topoisomerase II by stabilizing the enzyme-DNA intermediates in which topoisomerase subunits are covalently linked to DNA through 5-phosphotyrosyl linkages, thereby interfering with DNA repair and replication, RNA and protein synthesis. This agent possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. XK469R is more water soluble and active than the pure isomers, R( )XK469 and S(-)XK469. (NCI05);

CAS number : 157542-91-1;

Molecule name : XK469R;

NSC code : 698215;

Details

Origin ID

C2825;

UMLS CUI

C4721675;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- XK 469 [MeSH concept]
- XK 469 [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Topoisomerase II [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Repair Inhibition [NCIt concept]
- DNA Replication Inhibition [NCIt concept]
- Multidrug Resistance Inhibition [NCIt concept]
- RNA Synthesis Inhibition [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Topoisomerase II [NCIt concept]

Keyword's position in hierarchy(ies) :

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