" /> Topoisomerase-II Inhibitor Racemic XK469 - CISMeF





Preferred Label : Topoisomerase-II Inhibitor Racemic XK469;

NCIt synonyms : XK469 Racemic; Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]-phenoxy]-, ( /-)-;

NCIt definition : The racemic form of a synthetic quinoxaline phenoxypropionic acid derivative with antineoplastic properties. XK469R selectively inhibits topoisomerase II by stabilizing the enzyme-DNA intermediates in which topoisomerase subunits are covalently linked to DNA through 5-phosphotyrosyl linkages, thereby interfering with DNA repair and replication, RNA and protein synthesis. This agent possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. XK469R is more water soluble and active than the pure isomers, R( )XK469 and S(-)XK469. (NCI05);

CAS number : 157542-91-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 157542-91-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : XK469R;

NSC code : 698215;

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14/05/2024


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