Topoisomerase II

Preferred Label : Topoisomerase II;

NCIt synonyms : DNA Topoisomerase II; Topo II; TOP2; Topoisomerase 2; Topoisomerase-II;

NCIt definition : Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The topoisomerase II reaction appears to involve crossing-over of two DNA segments. Human cells contain two topoisomerase II isozymes: alpha and beta from distinct genes. DNA topoisomerase II alpha is associated with the Pol II holoenzyme and is required for chromatin-dependent co-activation. Transcription results in superhelical tension; topoisomerase II relaxation activity is essential for productive RNA synthesis on nucleosomal DNA. (from OMIM 126430 and NCI);

NCIt note : DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA.;

Details

Origin ID

C18434;

UMLS CUI

C0012863;

Automatic exact mappings (from CISMeF team)
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO term]
- Topoisomerase, dna, II, alpha [OMIM gene]
Currated CISMeF NLP mapping
- DNA topoisomerases, type II [MeSH concept]
- DNA topoisomerases, type II [MeSH Descriptor]
See also inter- (CISMeF)
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DNA topoisomerases, type II [MeSH Descriptor]
- DNA topoisomerases, type II [MeSH concept]
- Deoxyribonucleic acid topoisomerase (adenosine triphosphate-hydrolysing) (substance) [SNOMED CT concept]
- dna topoisomerase (atp-hydrolysing) [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Topoisomerase-II Inhibitor Racemic XK469 [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Proliferation Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Replication [NCIt concept]
- Transcription [NCIt concept]
is_target
- Amonafide L-Malate [NCIt concept]
- Amrubicin [NCIt concept]
- Amrubicin Hydrochloride [NCIt concept]
- Annamycin Liposomal [NCIt concept]
- Banoxantrone [NCIt concept]
- Berubicin Hydrochloride [NCIt concept]
- Camsirubicin [NCIt concept]
- Daunorubicin [NCIt concept]
- Daunorubicin Hydrochloride [NCIt concept]
- Doxorubicin [NCIt concept]
- Doxorubicin Hydrochloride [NCIt concept]
- Doxorubicin Prodrug/Prodrug-activating Biomaterial SQ3370 [NCIt concept]
- Doxorubicin-Eluting Beads [NCIt concept]
- Epirubicin [NCIt concept]
- Epirubicin Hydrochloride [NCIt concept]
- Etoposide [NCIt concept]
- Etoposide Phosphate [NCIt concept]
- Idarubicin [NCIt concept]
- Idarubicin Hydrochloride [NCIt concept]
- Idronoxil [NCIt concept]
- Liposomal Daunorubicin Citrate [NCIt concept]
- Liposome-Encapsulated Doxorubicin Citrate [NCIt concept]
- Liposome-encapsulated Daunorubicin-Cytarabine [NCIt concept]
- Lucanthone [NCIt concept]
- Lyso-Thermosensitive Liposome Doxorubicin [NCIt concept]
- Micellar Nanoparticle-encapsulated Epirubicin [NCIt concept]
- Micro Needle Array-Doxorubicin [NCIt concept]
- Mitoxantrone [NCIt concept]
- Mitoxantrone Hydrochloride [NCIt concept]
- PVA Microporous Hydrospheres/Doxorubicin Hydrochloride [NCIt concept]
- Pegylated Liposomal Doxorubicin Hydrochloride [NCIt concept]
- Pyrazoloacridine [NCIt concept]
- Teniposide [NCIt concept]
- Tirapazamine [NCIt concept]
- Topoisomerase I/II Inhibitor NEV-801 [NCIt concept]
- Topoisomerase-II Inhibitor Racemic XK469 [NCIt concept]

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